Preheat the oven to 350°F (175°C).
Line a loaf pan with aluminum foil for easy cleanup.
In a large bowl, add ground beef, onion, and garlic.
Add the egg, bread crumbs, and half of the ketchup.
Add Worcestershire sauce, mustard powder, salt, and pepper.
Mix the ingredients until just combined. Avoid overmixing.
Transfer the mixture to the loaf pan and shape it.
In a small bowl, mix the remaining ketchup and brown sugar.
Spread the ketchup glaze over the meatloaf.
Bake for 1 hour or until the internal temperature is 160°F.
Remove from the oven and let it rest for 10 minutes.
Slice and serve the meatloaf. Enjoy!